| Description | Dihomo-γ-linolenic acid (DGLA) is a fatty acid widely found in plants with antitumor and antiproliferative effects, inhibits the growth of xenograft tumor cells, and can be used in the study of inflammation-related diseases such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis. |
| In vitro | 在 THP-1 巨噬细胞中，Dihomo-γ-linolenic acid (50 μM；24小时）能够减弱干扰素-γ（IFN-γ）诱导的 STAT1 丝氨酸 727 位点的磷酸化[2]。 |
| In vivo | 在 48 只四周大的雌性裸鼠中，（每只鼠 8 mg；口服灌胃，每周两次，持续 35 天），能够抑制 D5D-KD 肿瘤的转移潜力[3]。 |
| Synonyms | Diroleuton, all-cis-8,11,14-Eicosatrienoic acid, Ro 12-1989 |
| molecular weight | 306.48 |
| Molecular formula | C20H34O2 |
| CAS | 1783-84-2 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (261.03 mM), Sonication is recommended. |
| References | 1. Wang X, et al. Multiple roles of dihomo-γ-linolenic acid against proliferation diseases. Lipids Health Dis. 2012 Feb 14;11:25. 2. Gallagher H, et al. Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2538-2550. 3. Yang X, et al. Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA. Redox Biol. 2019 Jan;20:236-246. |