| Description | Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6. |
| In vitro | 14-deoxyandrographolide(14-DAG) 处理激活了AMPK，这一过程通过诱导环磷酸腺苷-蛋白激酶A途径实现 [1]。14-DAG 下调了诱导细胞死亡信号复合体的形成，从而降低了肝细胞对TNF-α诱导的凋亡的敏感性。通过14-DAG 预处理肝细胞，通过诱导NO/cGMP途径，加强了微粒体Ca-ATPase活性 [2]。在10-100 μM的浓度范围内，14-DAG 以剂量依赖的方式降低了细胞外酸化率和细胞内碱化。此外，14-DAG 在存在外源性钙的条件下，减少了PAF诱导的钙通量，以及与MAPK(ERK1)相对应的44 kDa蛋白的酪氨酸磷酸化 [3]。 |
| In vivo | 14-DAG对乙醇引起的肝损伤的保护作用基于其通过cNOS依赖的方式改善氧化还原状态，从而减少氧化应激。14-DAG促进腺苷酸环化酶-cAMP信号通路的激活，进而上调cNOS，可能为慢性酗酒期间肝脏疾病的预防提供一种有前景的方法[4]。 |
| Synonyms | 去氧穿心莲内酯, 14-deoxyandrographolide |
| molecular weight | 334.45 |
| Molecular formula | C20H30O4 |
| CAS | 79233-15-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (29.9 mM) |
| References | 1. Arha D, et al. Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo. Eur J Pharmacol. 2015 Dec 5;768:207-16. 2. Xin XL, et al. Microbial transformation of deoxyandrographolide by Fusarium graminearum AS 3.4598. J Asian Nat Prod Res. 2011 Apr;13(4):350-5. 3. Deng S, et al. Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1615-8. 4. Xu Y, et al. Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities. Bioorg Med Chem. 2019;27(11):2209-2219. |