| Description | Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effect, it could significantly prevent the progression of diabetic nephropathy possibly attribute to down-regulation of the TGF-β/Smad pathway and rebalance the deposition and degradation of ECM proteins. |
| Synonyms | L-Dencichin, ODAP, Dencichin, 三七素 |
| molecular weight | 176.13 |
| Molecular formula | C5H8N2O5 |
| CAS | 5302-45-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Xie G X, et al. Analysis of dencichine in Panax notoginseng by gas chromatography–mass spectrometry with ethyl chloroformate derivatization[J]. Journal of Pharmaceutical & Biomedical Analysis, 2007, 43(3):920-925. 2. Li J, et al. Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-β/Smad signalling pathway[J]. European Journal of Pharmacology, 2017, 812:196. |