| Description | 1. Demethoxycurcumin (Desmethoxycurcumin) has antioxidant activity. 2. Demethoxycurcumin has anti-inflammatory activity. 3. Demethoxycurcumin has anti-proliferative activity. 4. Demethoxycurcumin has anti-acanthamoebic effect. 5. Demethoxycurcumin is a potential additive natural product in combination with chemotherapeutic agents in drug-resistant cancers. 6. Demethoxycurcumin inhibits energy metabolic and oncogenic signaling pathways through AMPK activation in triple-negative breast cancer cells. |
| Target activity | BACE1:17 μM |
| Synonyms | Curcumin II, 去甲氧基姜黄素, Desmethoxycurcumin, 脱甲氧姜黄, Monodemethoxycurcumin |
| molecular weight | 338.35 |
| Molecular formula | C20H18O5 |
| CAS | 22608-11-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (147.78 mM) |
| References | 1. Shieh J M , Chen Y C , Lin Y C , et al. Demethoxycurcumin Inhibits Energy Metabolic and Oncogenic Signaling Pathways through AMPK Activation in Triple-Negative Breast Cancer Cells[J]. Journal of Agricultural and Food Chemistry, 2013, 61(26):6366-6375. |