| Description | Demeclocycline (Declostatin) is a tetracycline antibiotic produced by a strain of Streptomyces aureofaciens.Demeclocycline has antimicrobial activity and inhibits the action of vasopressin on the renal tubules, leading to diuresis. Demeclocycline can be used to induce diuresis and acute renal failure. |
| In vitro | Demeclocycline (10 μM; 24 h)是一种新型的 BTICs 生长抑制剂，可以直接促进单核细胞和巨噬细胞的活性[4]。 |
| In vivo | Demeclocycline（ 40 mg/kg；腹腔注射;每天一次，持续48小时）结果显示尿量增加，尿渗透压降低，并导致尿水分数排泄显著增加[3]。 |
| Synonyms | Ledermycin, Bioterciclin, Deteclo, Declostatin, Deganol |
| molecular weight | 464.85 |
| Molecular formula | C21H21ClN2O8 |
| CAS | 127-33-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 20 mg/mL (43.02 mM), Sonication is recommended. DMSO: 10 mg/mL (21.51 mM), Sonication is recommended. |
| References | 1. I Chopra, et al. Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother. 1992 Mar;29(3):245-77. 2. D Schnappinger, et al. Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Arch Microbiol. 1996 Jun;165(6):359-69. 3. Marleen L A Kortenoeven, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18. 4. Susobhan Sarkar, et al. Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes. Front Immunol. 2020 Feb 21;11:272. |