| Description | Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in vascular relaxation. At the dose of 1-40 μM, epithelial growth factor receptor signaling and estrogen receptor α expression were inhibited, which was associated with apoptosis and autophagy. Delphinidin chloride regulates JAK/STAT3 and MAPKinase signaling. Delphinidin also inhibited the histone acetyltransferase activity of p300/CBP (IC50 was about 30 μM). |
| In vitro | It also inhibits signaling through epithelial growth factor receptors, suppressing the expression of estrogen receptor α and inducing both apoptosis and autophagy at a dose of 1-40 μM.[1][2] |
| In vivo | The effects of IdB 1056 observed in vivo at the microcirculatory level prevent the injury to endothelial cell function associated with diabetes and/or oxidative stress.[3] |
| molecular weight | 338.7 |
| Molecular formula | C15H11ClO7 |
| CAS | 528-53-0 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 56.2 mg/mL (166.1 mM), Sonication is recommended. |
| References | 1. Ozbay T, et al. Delphinidin Inhibits HER2 and Erk1/2 Signaling and Suppresses Growth of HER2-Overexpressing and Triple Negative Breast Cancer Cell Lines. Breast Cancer (Auckl). 2011;5:143-154. 2. Aiyer HS, et al. Influence of berry polyphenols on receptor signaling and cell-death pathways: implications for breast cancer prevention. J Agric Food Chem. 2012;60(23):5693-5708. 3. Bertuglia S, et al. Effects of the natural flavonoid delphinidin on diabetic microangiopathy. Arzneimittelforschung. 1995;45(4):481-485. 4. Holton TA, et al. Cloning and expression of cytochrome P450 genes controlling flower colour. Nature. 1993;366(6452):276-279. 5. Seong AR, et al. Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-κB acetylation in fibroblast-like synoviocyte MH7A cells. Biochem Biophys Res Commun. 2011;410(3):581-586. |