| Description | 1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important role in the transportation of Dauricine across the blood-brain barrier. 3. Dauricine may has anti-tumor effect, can inhibit tumor cells in urinary system and colon cancer cell proliferation, invasion; induce cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes. |
| Synonyms | 蝙蝠葛碱 |
| molecular weight | 624.77 |
| Molecular formula | C38H44N2O6 |
| CAS | 524-17-4 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 91 mg/mL(145.7 mM) Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble |
| References | 1. Wang J , Li Y , Zu X B , et al. Dauricine can inhibit the activity of proliferation of urinary tract tumor cells[J]. Asian Pacific Journal of Tropical Medicine, 2012, 5(12):973-976. |