| Description | Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium. |
| In vitro | 灌胃小鼠Sodium Danshensu,LD50: 2356.33 mg/kg;静脉注射大鼠Sodium Danshensu,LD50:>1500 mg/kg. |
| In vivo | Danshensu是有效的自由基清除剂和抗氧化剂。Sodium danshensu对血管张力表现出双向作用。低剂量的Sodium danshensu可能通过瞬时增强Ca2+内流产生小的收缩,高剂量主要通过促进血管平滑肌细胞中非选择性K+通道和小电导钙敏感性钾通道的开放而产生显着的血管舒张。Sodium danshensu在游离Ca(2+)培养基中,也会抑制去氧肾上腺素和CaCl2诱导的血管收缩。用sodium danshensu预培养能够抑制去氧肾上腺素和氯化钾剂量依赖性诱导的血管收缩。 |
| Synonyms | Sodium Danshensu, (±)-DanShenSu sodium salt, 丹参素钠, (±)-DanShenSu sodium sal |
| molecular weight | 220.16 |
| Molecular formula | C9H9NaO5 |
| CAS | 67920-52-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 2 mg/mL (9.08 mM) DMSO: 50 mg/mL (227.11 mM), Heating is recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Zhao GR, et al. Food Chem Toxicol, 2008, 46(1), 73-81. 2. Zhang N, et al. Acta Pharmacol Sin, 2010, 31(4), 421-428. 3. Ren R, et al. Toxicol Mech Methods, 2010, 20(8), 510-514. |