| Description | Cynarin (1,5-Dicaffeoylquinic acid) has neuroprotective, and antioxidant effects, it can inhibition of GSK3β as well as the modulation of Bcl-2/Bax. |
| In vitro | 1,5-Dicaffeoylquinic acid has protective effects against MPP~+ induces neurotoxicity of PC12 Cells, it (50 umol/L) pretreatment can inhibit the MPP+-induced up-regulation of the expression of α-synuclein mRNA and protein.1, 5-diCQA has antioxidant signaling properties that upregulate GSH synthesis by stimulating the Nrf2 pathway in astrocytes and protects them from cell death in an in vitro model of ischemia/reperfusion[1].1,5-Dicaffeoylquinic acid decreases the expression and protein levels of inducible nitric oxide synthase (iNOS) when used at a concentration of 10 μM in human coronary artery smooth muscle cells (HCASMCs) treated with a cytokine mixture[2]. |
| Synonyms | Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-, Cynarine, 1,5-Dicaffeoylquinic acid, 洋蓟素, 金银花 |
| molecular weight | 516.45 |
| Molecular formula | C25H24O12 |
| CAS | 30964-13-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 23 mg/mL (44.53 mM) |
| References | 1. Cao X, et al. 1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes.Brain Res. 2010 Aug 6;1347:142-8 2. Xia N , Pautz A , Wollscheid U , et al. Artichoke, Cynarin and Cyanidin Downregulate the Expression of Inducible Nitric Oxide Synthase in Human Coronary Smooth Muscle Cells[J]. Molecules, 2014, 19(3):3654-3668. |
| Kinase | The processing of an in vitro model of ischemia/reperfusion was described previously. The cultures were washed three times with deoxygenated glucose-free DMEM and placed into an anaerobic chamber with an atmosphere of 10% H2, 85% N2, and 5% CO2 for 4 h. Then the glucose-free DMEM was replaced with complete medium, and the culture plates were maintained at 37 C in a humidified 5% CO2-containing atmosphere for an additional 20 h. As a pretreatment, different concentrations of 1, 5-diCQA were added to the media before OGD for 2 h[1]. |