| Description | Cyclo(Phe-Gly) shows weak antagonistic activity against VEGFR2 -CD, it also shows strong inhibitory activity against human cancer cells(KB,KBv200) with LD50 at 6.5 and 11.2 umol/L,respectively. |
| In vitro | To discover antagonists of VEGFR2-CD from the fermentation broth produced by streptomyces strain I06A-02832. METHODS AND RESULTS:Under the guidance of ELISA assay against VEGFR2-CD, Compounds 2832 B and 2832 C were isolated and purified by combination of different column chromatographies and HPLC. The structures of compounds 2832 B and C were identified by combination of analysis of UV, IR, MS and 1D-NMR, 2D-NMR. Compounds 2832 B and 2832 C were purified and structurally identified as cyclic dipeptides, and were the same with cyclo-(Pro-Tyr) and Cyclo(Phe-Gly) respectively. Compounds 2832 B and 2832 C showed weak antagonistic activity against VEGFR2-CD by ELISA assay. CONCLUSIONS: They are firstly reported compounds 2832 B and 2832 C had antagonistic activity against VEGFR2-CD. |
| molecular weight | 204.23 |
| Molecular formula | C11H12N2O2 |
| CAS | 5037-75-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Discovery on antagonists of VEGFR2-CD produced by Streptomyces strain I06A-02832 Chinese Journal of Antibiotics,2014,6:408-12,421. |