| Description | Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer. Crocin suppresses tumor necrosis factor (TNF)alpha-induced apoptosis of pheochromocytoma (PC12) cells by modulating mRNA expressions of Bcl-2 family proteins, which trigger downstream signals culminating in caspase-3 activation followed by cell death. Crocin prevented the activation of nSMase by enhancing the transcription of gamma-glutamylcysteinyl synthase, which contributes to a stable glutathione supply that blocks the activity of nSMase. |
| Synonyms | 西红花苷, 藏红花, Gardenia Yellow, Alpha-Crocin, 藏红花素 |
| molecular weight | 976.96 |
| Molecular formula | C44H64O24 |
| CAS | 42553-65-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 9.77 mg/mL (10 mM) |
| References | 1. Sapanidou V, et al. Theriogenology. 2015 Nov;84(8):1273-82. 2. Liu Y, Yao C, Wang Y, et al. Protective Effect of Crocin on Liver Function and Survival in Rats With Traumatic Hemorrhagic Shock[J]. Journal of Surgical Research. 2021, 261: 301-309. 3. Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 |