| Description | Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L group, respectively; the mechanism is related to the alterations of Fas/Bcl-2 expression and caspase-3 activity. |
| In vitro | The following terminal concentrations of Crenulatin were used in the study: 25 mg/L and 100 mg/L. Apoptosis of mouse cerebral microvascular endothelial cells (bEnd. 3 cell line) was evaluated by flow cytometer, immunocytochemical assay (Fas, Bcl - 2) and Western blotting (caspase - 3) after culture for 24 h. Compared with control group, apoptosis of bEnd. 3 cells in 25 mg/L group was significantly inhibited ( P |
| molecular weight | 248.275 |
| Molecular formula | C11H20O6 |
| CAS | 63026-02-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Dual- direction effect of crenulatin on apoptosis of cerebral microvascular endothelial cells and it's mechanismChinese Journal of Pathophysiology, 2005, 21(11):2086-2090. |