| Description | Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases. |
| In vitro | Coumestrol在MCF-7细胞中抑制增殖并诱导凋亡，这一过程可被铜螯合剂neocuproine和ROS清除剂所阻止。Coumestrol处理导致ROS产生、DNA碎片化、p53/p21上调、细胞周期在G1/S阶段停滞、线粒体膜去极化以及caspases 9/3的激活[1]。此外，Coumestrol降低ES2（来源于清晰细胞/浆液性癌）细胞的活性和侵袭性，并诱导凋亡。同时，其处理还减弱了卵巢癌增殖标志物immunoreactive PCNA和ERBB2的表达，并导致ES2细胞死亡。在剂量和时间依赖性方面，Coumestrol处理还使AKT, p70S6K, ERK1/2, JNK1/2和p90RSK的磷酸化失活[2]。 |
| Synonyms | 拟雌内酯, 考迈斯托醇 |
| molecular weight | 268.22 |
| Molecular formula | C15H8O5 |
| CAS | 479-13-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25mg/mL (93.21 mM) Methanol: 20 mg/mL (74.57 mM) |
| References | 1. Zafar A, et al. Cytotoxic activity of soy phytoestrogen coumestrol against human breast cancer MCF-7 cells: Insights into the molecular mechanism. Food Chem Toxicol. 2017 Jan;99:149-161. 2. Lim W, et al. Coumestrol suppresses proliferation of ES2 human epithelial ovarian cancer cells. J Endocrinol. 2016 Mar;228(3):149-60. |