| Description | Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway. |
| Synonyms | 柯诺辛, 柯诺辛碱 |
| molecular weight | 384.47 |
| Molecular formula | C22H28N2O4 |
| CAS | 6877-32-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 50 mg/mL H2O: Insoluble DMSO: 55 mg/mL (143.05 mM) |
| References | 1. Chen LL, et al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J Neuroimmune Pharmacol. 2014 Jun;9(3):380-7. 2. Sakakibara I, et al. Effect on locomotion of indole alkaloids from the hooks of uncaria plants. Phytomedicine. 1999 Jul;6(3):163-8. |