| Description | Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese). |
| In vitro | Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA [1]. |
| In vivo | Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice [2]. |
| Synonyms | 柯诺辛碱 B, 柯诺辛碱B |
| molecular weight | 384.47 |
| Molecular formula | C22H28N2O4 |
| CAS | 17391-18-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (208.07 mM) |
| References | 1. Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54. 2. Sakakibara I, et al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine. 1998 Apr;5(2):83-6. |