| Description | Coryneine (Trimethyl(3,4-dihydroxyphenethyl)aminium) is a quaternary ammonium derivative of dopamine derived from aconite root. |
| In vivo | Coryneine（20-150微摩尔）可阻断由神经引发的肌肉抽搐反应，而不影响通过电刺激引发的肌肉收缩[1]。Coryneine（20微摩尔-2毫摩尔）能够使端板膜去极化，这一效应可被1及5微摩尔的潘库溴铵可逆地抑制[1]。Coryneine（30微摩尔-10毫摩尔）以剂量依赖的方式引发去神经肌肉的收缩，其效应可被70纳摩尔的潘库溴铵减少70%[1]。 |
| Synonyms | 2-(3,4-dihydroxyphenyl)ethyl-trimethylazanium, Quaternary dopamine, Trimethyl(3,4-dihydroxyphenethyl)aminium, 棍掌碱, Dopamine methiodide |
| molecular weight | 196.27 |
| Molecular formula | C11H18NO2 |
| CAS | 7224-66-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 70 mg/mL (356.65 mM) |
| References | 1. Kimura M, Kimura I, Muroi M, Nojima H, Diwan PV. Depolarizing neuromuscular blocking action of coryneine derived from aconite root in isolated mouse phrenic nerve-diaphragm muscles. Biol Pharm Bull. 1995 May;18(5):691-5. 2. Nojima H, Okazaki M, Kimura I. Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice. J Asian Nat Prod Res. 2000;2(3):195-203. 3. Barlow RB. The effects of pH on the activity of coryneine and related phenolic quaternary ammonium salts on the frog rectus preparation. Br J Pharmacol. 1976 Aug;57(4):517-9. |