| Description | Coenzyme Q9 (Ubiquinone 9) (CoQ9) is a normal constituent of human plasma. CoQ9 in human plasma may originate as a product of incomplete CoQ10 biosynthesis or from the diet. |
| In vitro | Coenzyme Q9 were cardioprotective, as evidenced by their abilities to improve left ventricular performance and to reduce myocardial infarct size and cardiomyocyte apoptosis[1]. |
| In vivo | Mutations in the gene that encodes Coenzyme Q9(CoQ9) are associated with encephalomyopathy and autosomal-recessive, neonatal-onset, primary CoQ10 deficiency.While in humans CoQ10 predominates, mice and C. elegans primarily rely on CoQ9 for electron transport through the mitochondrial respiratory chain and for antioxidant functions[2,3]. |
| Animal experiments | Guinea pigs were randomly divided into three groups: groups I and II were fed CoQ 9 and CoQ10, respectively, for 30 days while group III served as control.?After 30 days, the guinea pigs were sacrificed and isolated hearts were perfused via working mode were subjected to 30 min ischemia followed by 2 h of reperfusion.?Cardioprotection was assessed by evaluating left ventricular function, ventricular arrhythmias, myocardial infarct size, and cardiomyocyte apoptosis.?Samples of hearts were examined for the presence of CoQ9 and CoQ10[1]. |
| Synonyms | 辅酶Q9, Ubiquinone Q9, Ubiquinone 9, CoQ9 |
| molecular weight | 795.23 |
| Molecular formula | C54H82O4 |
| CAS | 303-97-9 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1mg/ml (insoluble） |
| References | 1. Lekli I, et al. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10. J Agric Food Chem. 2008 Jul 9;56(13):5331-7. 2. Duncan, A.J., Bitner-Glindzicz, M., Meunier, B., et al. A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: A potentially treatable form of mitochondrial disease.American Journal of Human Genetics 84(5), 558-566 (2009). 3. Lapointe, J., Wang, Y., Bigras, E., et al. The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/- mice. Journal of Cell Biology 199(2), 215-224 (2012). |