| Description | Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin A can be used in studies about the prevention of LDL oxidation in atherosclerotic lesions. |
| In vitro | Cleomiscosin A protects against the oxidative modification of apoB-100 induced by either Cu2+ or HOCl with IC50s of 13.4 and 8.1 μM, respectively[3]. |
| molecular weight | 386.35 |
| Molecular formula | C20H18O8 |
| CAS | 76948-72-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1.9 mg/mL (5 mM) |
| References | 1. Sharma S, et al. Synthesis and anti-inflammatory activity of derivatives of coumarino-lignoid, cleomiscosin A and its methyl ether. Eur J Med Chem. 2010;45(11):5150-5156. 2. Ma M, et al. [Chemical constituents from branch of Macaranga adenantha and their TNF-alpha inhibitory activity]. Zhongguo Zhong Yao Za Zhi. 2007 Jun;32(12):1175-9. Chinese. 3. Jin W, et al. Antioxidant activity of cleomiscosins A and C isolated from Acer okamotoanum. Arch Pharm Res. 2007 Mar;30(3):275-81. |