| Description | Citronellal ((±)-Citronellal) is a monoterpene predominantly formed by the secondary metabolism of plants, producing antithrombotic, antiplatelet, and antihypertensive activities. |
| In vitro | Administrations of Citronellal(CT) (50, 100, and 150?mg/kg) as well as lovastatin dramatically reduced the size of carotid atherosclerotic plaque in rats in a dose-dependent manner, compared with atherosclerotic rats fed with a high-fat diet plus balloon injury and vitamin D3. Mechanically, CT improved endothelial dysfunction, increased cell migration, and suppressed oxidative stress and inflammation in vascular endothelium in rats feeding on the high-fat diet plus balloon injury. Further, CT downregulated the protein levels of sodium-hydrogen exchanger 1 in rats with atherosclerosis[1]. |
| Cell experiments | An AS model in carotid artery was induced by balloon injury and vitamin D3 injection in rats fed with a high-fat diet. The size of the carotid atherosclerotic plaque was determined by ultrasound, oil red, and hematoxylin-eosin staining. Endothelial function was assessed by measuring acetylcholine-induced vessel relaxation in an organ chamber[1]. |
| Synonyms | (±)-Citronellal, 香茅醛 |
| molecular weight | 154.25 |
| Molecular formula | C10H18O |
| CAS | 106-23-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (194.49 mM) |
| References | 1. Lu J X , Guo C , Ou W S , et al. Citronellal prevents endothelial dysfunction and atherosclerosis in rats[J]. Journal of Cellular Biochemistry, 2018. 2. Araújo-Filho JV, Ribeiro WLC, André WPP,et al.Anthelmintic activity of Eucalyptus citriodora essential oil and its major component, citronellal, on sheep gastrointestinal nematodes.Rev Bras Parasitol Vet. 2019 Nov 25. pii: S1984-29612019005022101. |