| Description | Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection. |
| Synonyms | Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-, 4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol, 鼓槌石斛素 |
| molecular weight | 318.36 |
| Molecular formula | C18H22O5 |
| CAS | 156951-82-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/ml (172.76 mM) |
| References | 1. Bhummaphan N, Pongrakhananon V, Sritularak B, Chanvorachote P. Cancer Stem Cell Suppressing Activity of Chrysotoxine, a bibenzyl from Dendrobium pulchellum. J Pharmacol Exp Ther. 2017 Dec 7. pii: jpet.117.244467. doi: 10.1124/jpet.117.244467. 2. Fan J, Guan L, Kou Z, Feng F, Zhang Y, Liu W. Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:57-62. doi: 10.1016/j.jchromb.2014.07.011. Epub 2014 Jul 16. 3. Chanvorachote P, Kowitdamrong A, Ruanghirun T, Sritularak B, Mungmee C, Likhitwitayawuid K. Anti-metastatic activities of bibenzyls from Dendrobium pulchellum. Nat Prod Commun. 2013 Jan;8(1):115-8. PubMed PMID: 23472473. 4. Song JX, Shaw PC, Wong NS, Sze CW, Yao XS, Tang CW, Tong Y, Zhang YB. Chrysotoxine, a novel bibenzyl compound selectively antagonizes MPP⁺, but not rotenone, neurotoxicity in dopaminergic SH-SY5Y cells. Neurosci Lett. 2012 Jul 11;521(1):76-81. doi: 10.1016/j.neulet.2012.05.063. Epub 2012 Jun 1. PubMed PMID: 22659498. |