| Description | Chlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation. In a mouse model of implanted fibrosarcoma, Chlorin E6 (2.5-10 mg/kg, i.v., 50-200 J/cm2 irradiation) resulted in complete tumor disappearance after varying degrees of irradiation. Agents including Chlorin E6 were tested in a Phase I clinical study in patients with early superficial squamous cell carcinoma of bronchial origin with favorable results (40 mg/m2, IV, 100 J/cm2 laser irradiation). In a Phase II clinical trial in patients with early stage lung cancer, the same mode of administration resulted in a complete response in 82.9% of patients. Chlorin E6 has been investigated as a nanotechnology drug delivery tool. |
| Synonyms | Ce6, Chlorin e6, CE6 |
| molecular weight | 596.67 |
| Molecular formula | C34H36N4O6 |
| CAS | 19660-77-6 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 11.93 mg/mL (20 mM) DMF: 11.93 mg/mL (20 mM) Ethanol: Slightly Soluble |
| References | 1. Pinto JG, et al. Chlorin E6 phototoxicity in L. major and L. braziliensis promastigotes-In vitro study [published correction appears in Photodiagnosis Photodyn Ther. 2017 Dec;20:287]. Photodiagnosis Photodyn Ther. 2016;15:19-24. 2. Akhlynina TV, et al. Nuclear targeting of chlorin e6 enhances its photosensitizing activity. J Biol Chem. 1997;272(33):20328-20331. 3. Nishie H,et al. Excellent antitumor effects for gastrointestinal cancers using photodynamic therapy with a novel glucose conjugated chlorin e6. Biochem Biophys Res Commun. 2018;496(4):1204-1209. 4. Merlin JL, et al. The multidrug resistance modulator SDZ-PSC 833 potentiates the photodynamic activity of chlorin e6 independently of P-glycoprotein in multidrug resistant human breast adenocarcinoma cells. Int J Oncol. 2003;22(4):733-739. |