| Description | Chelidonine hydrochloride is one of the alkaloids of Chelidonium majus, which has broad pharmacological activities |
| In vitro | Chelidonine significantly suppressed LPS-induced the production of NO and PGE2, as well as iNOS and COX-2 mRNA and protein expression.?In addition, pro-inflammatory cytokines induced by LPS, such as TNFα and IL-6 were also attenuated by chelidonine.?What's more, LPS-induced activation and degradation of IκBα followed by translocation of the p65 from the cytoplasm to the nucleus were attenuated by chelidonine.?Furthermore, chelidonine even significantly inhibited TLR4 expression induced by LPS[1]. |
| molecular weight | 389.83 |
| Molecular formula | C20H20ClNO5 |
| CAS | 4312-31-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: <10mM |
| References | 1. Wang L , Xiaojie H , Zhuwen Y , et al. Chelidonine suppresses LPS-Induced production of inflammatory mediators through the inhibitory of the TLR4/NF-κB signaling pathway in RAW264.7 macrophages[J]. Biomedicine & Pharmacotherapy, 2018, 107:1151-1159. 2. Pan J , Yang Y , Zhang R , et al. Enrichment of chelidonine from Chelidonium majus L. using macroporous resin and its antifungal activity[J]. Journal of Chromatography B, 2017, 1070:7. |