| Description | Chamaejasmenin B is a compound isolated from Stellera chamaejasme L. Chamaejasmenin B has anticancer and antitumor activity, inhibiting cancer cell migration and invasion, and inhibiting tumor metastasis.Chamaejasmenin B is used in the study of cancers such as breast cancer. |
| In vitro | Chamaejasmenin B在8种人类实体瘤细胞系（HepG2, SMMC-7721, A549, MG63, U2OS, KHOS, HCT-116, HeLa）中显示出显著的抗增殖作用，IC50值介于1.08至10.8 μmol/L之间。在对这两种化合物最敏感的A549和KHOS细胞中，其抗增殖效应的机制被明确了，这两种化合物显著诱导DNA损伤标志物γ-H2AX的表达以及细胞凋亡。此外，用这两种化合物处理细胞还显著引起G(0)/G(1)期阻滞。 |
| molecular weight | 570.54 |
| Molecular formula | C32H26O10 |
| CAS | 89595-71-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Li Q, et al. Chamaejasmenin B, an Inhibitor for Metastatic Outgrowth, Reversed M2-Dominant Macrophage Polarization in Breast Tumor Microenvironment. Front Immunol. 2021;12:774230. 2. Li Q, et al. Chamaejasmenin B, a novel candidate, inhibits breast tumor metastasis by rebalancing TGF-beta paradox. Oncotarget. 2016;7(30):48180-4819 3. Zhang C, Et al. In vitro anti-cancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L. Acta Pharmacol Sin. 2013;34(2):262-270. |