| Description | Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus. |
| In vitro | Cerulenin与StAR过表达具有相似效应。StAR通过减少主动脉内皮细胞中的脂质合成和摄取，以及减轻PA引起的炎症和一氧化氮(NO)生物可用性降低，从而缓解了由PA引发的内皮细胞功能障碍[1]。 |
| In vivo | 接受了cerulenin治疗的ob/ob肝脏的组织学剖析展现了脂质含量的显著降低，这种降低既与剂量相关又与时间相关。60 mg/kg cerulenin进行七天治疗，无论是每天还是隔天给药，均展示了最大幅度的脂肪染色减少，在肝脏的某些区域，ORO染色甚至完全消失（图3D-F）。60 mg/kg cerulenin的两天治疗结果显示脂肪含量有适度减少。相比之下，30 mg/kg的cerulenin的效果不如60 mg/kg剂量那样显著，但对于脂肪含量的影响仍然明显，除了两天治疗的情况（数据未示）[2]。 |
| molecular weight | 223.27 |
| Molecular formula | C12H17NO3 |
| CAS | 17397-89-6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90 mg/mL (403.10 mM), Sonication is recommended. |
| References | 1. Tian D, et al. Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability. Cardiovasc Diabetol. 2012 Nov 21;11:144. 2. Gang, Cheng, Arun, et al. Cerulenin Blockade of Fatty Acid Synthase Reverses Hepatic Steatosis in ob/ob Mice[J]. Plos One, 2013. |