| Description | cephalandole B, an indole alkaloid isolated from cyanide, significantly inhibited IL-17A gene expression and suppressed IL-17A luciferase reporter in Jukat cells in a dose-dependent manner. |
| In vitro | 从青黛中分离出两种吲哚生物碱，包括一种新的indigodole D和cephalandole B。cephalandole B对IL-17A蛋白分泌没有抑制作用。然而，这两种化合物尤其是cephalandole B，明显地以剂量依赖的方式在带有IL-17A荧光素酶报告基因的Jukat细胞中抑制了IL-17A基因的表达。[1] |
| molecular weight | 294.3 |
| Molecular formula | C17H14N2O3 |
| CAS | 915315-44-5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lee CL, et al. IL-17A inhibitions of indole alkaloids from traditional Chinese medicine Qing Dai. J Ethnopharmacol. 2020;255:112772. 2. Mason JJ, et al. Synthetic studies of cephalandole alkaloids and the revised structure of cephalandole A. J Nat Prod. 2008;71(8):1447-1450. |