| Description | Capsorubin is a carotenoid with a variety of biological activities. capsorubin inhibited lipid peroxidation induced by 2,2′-azino(2,4-dimethylvaleronitrile) (AMVN) at a concentration of 167 μM. capsorubin (1 μM) reduced uvb-induced DNA strand breaks and apoptosis in human dermal fibroblasts. formation. It also inhibited the activation of ebvirus early antigen (EBV-EA) induced by 12-carnosine 13-acetate fobo in Raji cells. |
| In vitro | Preincubation of human dermal fibroblasts (HDF) with capsorubin significantly counteracted UVB-induced cytotoxicity at doses between 0 and 300 mJ cm(-2). Pretreatment of HDF with capsorubin (1 μM) significantly decreased the formation of DNA strand breaks following irradiation with UVB light. Capsorubin studied decreased caspase-3 cleavage (a marker for UVB-induced apoptosis), however, caspase-dependent PARP-1 cleavage was not affected suggesting that the remaining caspase activity is sufficient to promote UVB-induced apoptosis. It is conceivable that capsorubin selectively interferes with cellular responses activated by UVB-mediated damage. Our findings indicate that capsorubin exhibits similar properties to lutein and could be used as a dietary supplement to improve natural photoprotection.[1] |
| molecular weight | 600.87 |
| Molecular formula | C40H56O4 |
| CAS | 470-38-2 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble DMF: Soluble |
| References | 1. Fernández-García E, et al. Carotenoids exclusively synthesized in red pepper (capsanthin and capsorubin) protect human dermal fibroblasts against UVB induced DNA damage. Photochem Photobiol Sci. 2016;15(9):1204-1211. 2. Nishino A, et al. Reaction of Paprika Carotenoids, Capsanthin and Capsorubin, with Reactive Oxygen Species. J Agric Food Chem. 2016;64(23):4786-4792. 3. Shim YS, et al. Simultaneous determination of free capsorubin and capsanthin in red pepper powder using u-HPLC. J AOAC Int. 2013;96(2):341-345. 4. Maeda H, et al. Biological Activities of Paprika Carotenoids, Capsanthin and Capsorubin. Adv Exp Med Biol. 2021;1261:285-293. |