C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))-product

Description	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) is the predominant sulfate analog in the mature myelin sheath. C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) interacted with C-type lectin and immunoglobulin-like receptors to give the highest affinity for LMIR5. Galactosylceramide (d18:1/24:1(15Z)) induces MCP-1 production by basophils, which activates NFAT by increasing LMIR5, but not mast cells .C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) binds in vitro to CD1d binding and increased the proliferation of free mouse splenocytes.
In vitro	The relationship between structure and activity (SAR) of newly synthesized sulfatide isoforms C24:1 was evaluated. The basal IDO1 expression was significantly increased by C24:1 sulfatide (+87 ± 7% and +50 ± 5% at 1μΜ, respectively) over negative controls ; These effects functionally correlated with changes in IDO1 activity: l-kynurenine contents in the culture media were significantly increased by C24:1 sulfatide (+61 ± 8% and +48 ± 4% at 1μM, respectively) over negative controls.[2]
Synonyms	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))
molecular weight	890.3
Molecular formula	C48H91NO11S
CAS	151057-28-2
Storage	store at low temperature　\|　Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	Chloroform:Methanol (5:1): Soluble
References	1. Moyano AL, et al. Levels of plasma sulfatides C18 : 0 and C24 : 1 correlate with disease status in relapsing-remitting multiple sclerosis. J Neurochem. 2013 ; 127(5):600-604. 2. Altomare E, et al. Synthetic isoforms of endogenous sulfatides differently modulate indoleamine 2,3-dioxygenase in antigen presenting cells. Life Sci. 2011 ; 89(5-6):176-181.

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C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))

CAS No.: 151057-28-2