| Description | C22 Ceramide (d18:1/22:0) (C22 Ceramide), a long-chain ceramide containing behenic acid, is an endogenous bioactive sphingolipid.C22-Ceramide specifically inhibits MCSR and reduces C16 ceramide channel formation in isolated rat liver mitochondria and liposomes. |
| Synonyms | Cer(d18:1/22:0), C22 Ceramide, Ceramide (d18:1/22:0) |
| molecular weight | 622.06 |
| Molecular formula | C40H79NO3 |
| CAS | 27888-44-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMF: 0.15 mg/mL DMSO: < 1mg/ml (insoluble） |
| References | 1. Stiban J, et al. Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis. Biochim Biophys Acta. 2015 Feb;1848(2):561-7. 2. Separovic D, et al. Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation. Int J Oncol. 2013 Dec;43(6):2064-72. |