| Description | C12-Ceramide (C12 Ceramide (d18:1/12:0)), a ceramide present in the protective membranes surrounding umbilical cord blood vessels in infants born to women with pre-eclampsia, can be used to assess the level of ASM activity in the plasma of patients with Niemann-Pick disease. |
| Synonyms | N-Laurylsphingosine, C12 Ceramide (d18:1/12:0), N-Lauroyl-D-erythro-sphingosine |
| molecular weight | 481.79 |
| Molecular formula | C30H59NO3 |
| CAS | 74713-60-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: >33 mg/mL DMF: 22 mg/mL DMSO: 20 mg/mL PBS (pH 7.2): <50μg/mL |
| References | 1. He X, et al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314(1):116-20. 2. Øverbye A, et al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8(44):76921-76934. |