| Description | C-Phycocyanin (C-PC) is a water-soluble protein pigment that is also used as a nutrient supplement for human beings. |
| In vitro | For the combination experiments, when cells treated with All-trans retinoic acid (ATRA) combined with C-phycocyanin, the IC50 value is lower than that in the ATRA group. But under the same IC50, the more C-phycocyanin is used, the less ATRA is needed. C-phycocyanin combined with ATRA can significantly decrease the CDK-4 mRNA level (P<0.05). The combination index (CI) value of the C-phycocyanin+ATRA combination group is 0.852 which is less than 1, indicating that the two drugs are synergetic under the action concentration (88 μg/L C-phycocyanin+0.102 mM ATRA). The expression of caspase-3 in the C-phycocyanin group is more than that in the control group but is similar to that in the ATRA group, whereas the expression in the combination group is maximum. |
| In vivo | Compare with the control group, the average tumor weights of mice in solely C-phycocyanin or ATRA treatment groups are significantly decreased, and further reduced in the C-phycocyanin+ATRA synergy group. Single C-phycocyanin can increase the spleen weight of mice but the effects of ATRA are just the opposite. C-phycocyanin can also promote the growth of immune organs in mice and increase the body's immune function. C-phycocyanin and ATRA alone can significantly inhibit Cyclin D1 expression, and when being combined, the inhibitory effect is more obvious. |
| Synonyms | C-PC, 藻蓝蛋白, C-藻蓝蛋白 |
| molecular weight | N/A |
| CAS | 11016-15-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 14.29 mg/mL, Sonication is recommended. |
| References | 1. Li B, et al. The synergistic antitumor effects of all-trans retinoic acid and C-phycocyanin on the lung cancer A549 cells in vitro and in vivo. Eur J Pharmacol. 2015 Feb 15;749:107-14. |