| Description | Bromelain is an anti-inflammatory drug derived from pineapple stem. It acts through down-regulation of plasma kininogen, degradation of advanced glycation end-product receptors, inhibition of Prostaglandin E2 expression, and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway. |
| In vivo | Bromelain（40 mg/kg；腹腔注射；每日；持续7天；雄性SD大鼠）的预处理能够降低帕金森病帕金森大鼠模型中的运动功能障碍。注射6-OHDA会导致严重的运动障碍，而在损伤前进行Bromelain 预处理可以预防该障碍的发生[1]。 |
| molecular weight | 1026.942 |
| Molecular formula | C39H66N2O29 |
| CAS | 9001-00-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.33 mg/mL (3.25 mM), Sonication is recommended. |
| References | 1. Adu TS, et al. Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Metab Brain Dis. 2019 Jul 22. 2. Pavan R, et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. |