| Description | Bisabolene (FEMA 3331) is a sesquiterpene extracted from oregano and other aromatic plants. It is a potential anticancer agent and studies have shown that it can induce apoptosis in the A549 cancer cell line. |
| Synonyms | Bisabolene (natural), 红没药烯, FEMA 3331, Limene |
| molecular weight | 204.35 |
| Molecular formula | C15H24 |
| CAS | 495-62-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Soluble |
| References | 1. Davies FK, Work VH, Beliaev AS, Posewitz MC. Engineering Limonene and Bisabolene Production in Wild Type and a Glycogen-Deficient Mutant of Synechococcus sp. PCC 7002. Front Bioeng Biotechnol. 2014 Jun 19;2:21. 2. Aschenbrenner AK, Kwon M, Conrad J, Ro DK, Spring O. Identification and characterization of two bisabolene synthases from linear glandular trichomes of sunflower (Helianthus annuus L., Asteraceae). Phytochemistry. 2016 Apr;124:29-37. 3. Jou YJ, Chen CJ, Liu YC, Way TD, Lai CH, Hua CH, Wang CY, Huang SH, Kao JY, Lin CW. Quantitative phosphoproteomic analysis reveals γ-bisabolene inducing p53-mediated apoptosis of human oral squamous cell carcinoma via HDAC2 inhibition and ERK1/2 activation. Proteomics. 2015 Oct;15(19):3296-309. 4. Jou YJ, Hua CH, Lin CS, Wang CY, Wan L, Lin YJ, Huang SH, Lin CW. Anticancer Activity of γ-Bisabolene in Human Neuroblastoma Cells via Induction of p53-Mediated Mitochondrial Apoptosis. Molecules. 2016 May 7;21(5). |