| Description | Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling. |
| In vitro | Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. BISA inhibited DC functions by blocking MAPK and NF-κB signaling[2]. |
| molecular weight | 248.32 |
| Molecular formula | C15H20O3 |
| CAS | 30557-81-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (100.68 mM) |
| References | 1. HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes.Fitoterapia. 2011 Apr;82(3):434-40. 2. Kim H S , Lee Y J , Lee H K , et al. Bisabolangelone inhibits dendritic cell functions by blocking MAPK and NF-κB signaling[J]. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association, 2013, 59. |