| Description | Biliatresone, an environmental toxin isolated from the coccolithophores Dysphania glomulifera and D. littoralis, induced C57BL/6J neonatal cholangiopathy, induced a decrease in glutathione (GSH) levels, induced a significant decrease in SOX17 cholangiocyte levels, and induced extrahepatic cholangiocyte damage and fibrosis in mice. |
| molecular weight | 328.32 |
| Molecular formula | C18H16O6 |
| CAS | 1801433-90-8 |
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (91.37 mM), Sonication is recommended. |
| References | 1. Kyung A Koo, et al. Biliatresone, a Reactive Natural Toxin From Dysphania Glomulifera and D. Littoralis: Discovery of the Toxic Moiety 1,2-Diaryl-2-Propenone. Chem Res Toxicol. 2015 Aug 17;28(8):1519-21. 2. Kristin Lorent, et al. Identification of a Plant Isoflavonoid That Causes Biliary Atresia. Sci Transl Med. 2015 May 6;7(286):286ra67. 3. Zhu JJ, Yang YF, Dong R, Zheng S. Biliatresone: progress in biliary atresia study. World J Pediatr. 2023 May;19(5):417-424. 4. Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E, Sokol RJ. Biliary Atresia: Clinical and Research Challenges for the Twenty-First Century. Hepatology. 2018 Sep;68(3):1163-1173. |