| Description | β-Elemene (Levo-β-elemene) is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis. |
| In vitro | β-Elemene 显著抑制了多药耐药性(MDR)胃癌细胞的体内外转移能力。从作用机理上看，β-Elemene 调控了 MMP-2/9 的表达，并逆转了上皮间质转化。β-Elemene 通过抑制 miR-1323 的表达上调了 Cbl-b，从而抑制了调控 MMP-2/9 的 EGFR-ERK/AKT 信号通路。在裸鼠模型中，β-Elemene 处理后肺部转移性肿瘤结节的数量显著减少。β-Elemene 通过调节 miR-1323/Cbl-b/EGFR 信号轴抑制了 MDR 胃癌细胞的转移[3]。 |
| Cell experiments | Cell viability assay was used to assess the resistance of SGC7901/ADR cells and the cytotoxic effects of β-Elemene.?Wound healing, transwell assay and lung metastatic mice model were used to the anti-metastasis effects of β-Elemene.?MicroRNA microarray analysis was used to explore potential regulated miRNAs.?Luciferase reporter assay was used to identify the direct target.?Human MMP antibody array, western blot, immunoprecipitation, qRT-PCR analyses and immunohistochemistry were conducted to investigate the underlying anti-metastasis mechanism of β-Elemene[3]. |
| Synonyms | (-)-β-Elemene, β-榄香烯, Levo-β-elemene, B-榄香烯 |
| molecular weight | 204.35 |
| Molecular formula | C15H24 |
| CAS | 515-13-9 |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (244.68 mM), Sonication is recommended. |
| References | 1. Ross, S.A., and ElSohly, M.A. The volatile oil composition of fresh and air-dried buds of Cannabis sativa. J. Nat. Prod. 59(1), 49-51 (1996). 2. Gan D, et al. β-elemene enhances cisplatin-induced apoptosis in bladder cancer cells through the ROS-AMPK signaling pathway.Oncol Lett. 2020 Jan;19(1):291-300. |