| Description | Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action. |
| In vitro | AZ（Azelaic acid）与taurine（Tau）联合使用在黑色素细胞中表现出比单独使用AZ更强的抑制效果。AZ与Tau的组合不仅能显著抑制B16F10黑色瘤细胞的黑色素产生和酪氨酸酶活性，且无明显细胞毒性。此外，这种化学组合的抑制效果在黑色素生成上也超过了单独使用AZ[2]。 |
| In vivo | Azelaic acid 显示出抗动脉粥样硬化效果。它的抗动脉粥样硬化作用与血浆脂质含量的变化无关。补充Azelaic acid 可使CD68巨噬细胞标记水平下降34%（p<0.05）[1]。 |
| Cell experiments | B16F10 melanoma cells are seeded at a density of 2.5×105 cells/60 mm culture dish. The cells are treated with Azelaic acid combined with Tau for 24 hr. The cells pellets are dissolved in 1 N NaOH at 60°C for 1 hr. The relative melanin content is determined by measuring the absorbance at 475 nm in ELISA reader. (Only for Reference) |
| Synonyms | Finacea, Azelex, 壬二酸, Nonanedioic acid, Anchoic acid |
| molecular weight | 188.22 |
| Molecular formula | C9H16O4 |
| CAS | 123-99-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 35 mg/mL (186 mM) DMSO: 55 mg/mL (292.21 mM) H2O: 34 mg/mL (180.6 mM) |
| References | 1. Litvinov D, et al. Atherosclerosis. 2010, 209(2):449-54. 2. Yu JS, et al. J Biomed Sci. 2010, 17 Suppl 1:S45. |