| Description | Azaserine (CI-337) is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase. |
| In vitro | Azaserine 抑制了己糖胺生物合成途径，该途径将过量的细胞内葡萄糖转化为UDP-N-乙酰基葡萄糖胺的生物合成以及O-连结糖蛋白的形成[2]。Azaserine（25 μM）抑制了参与核苷酸生物合成的谷氨酰胺依赖性酰胺转移酶，包括磷酰核糖基甲酰基甘氨酰胺合成酶和葡萄糖胺-6-磷酸异构酶[3]。 |
| Synonyms | CI-337, 偶氮丝胺酸, P-165, 氮杂丝氨酸, O-Diazoacetyl-L-serine |
| molecular weight | 173.13 |
| Molecular formula | C5H7N3O4 |
| CAS | 115-02-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 60 mg/mL (346.56 mM), Sonication is recommended. |
| References | 1. Wise DR, et al. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci. 2010 Aug;35(8):427-33. 2. Rajapakse AG, et al. The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H815-22. 3. Lyons SD, et al. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. J Biol Chem. 1990 Jul 5;265(19):11377-81. |