| Description | Astragaloside VI could improve wound healing by activating the EGFR/ERK signaling pathway. |
| In vitro | Pretreatment with Astragaloside VI (1 μM) increases EGFR activation in HaCaT cells. Astragaloside VI, a major intestinal metabolite of astragalosides, exerts the strongest EGFR activation. In HaCaT cells, the positive control, EGF expectedly results in a 1.5-fold increase in cell proliferation, compared to the control. Astragaloside VI at the indicated concentrations also significantly promotes cell proliferation in both HaCaT and HDF cells [1]. Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR/MAPK signaling cascades [2]. |
| In vivo | In the simple non-infected wound model, wound healing in mice is accelerated by Astragaloside VI, wherein the time required for wound closure is shortened by approximately 2-4 days, compared to that in the control group. Topical treatment with Astragaloside VI reduces the volume of pus produced, compared to the control group. Astragaloside VI treated wounds show an accelerated rate of healing, compared to the control and vaseline groups. By day 22, the Astragaloside VI -treated wounds fully close, whereas the blank and vaseline-treated wounds do not fully close until day 26. Astragaloside VI increases blood vessel formation in both the non-infected and infected wound models [1]. Astragaloside VI could effectively activate EGFR/MAPK signaling cascades, promote NSCs proliferation and neurogenesis in transient cerebral ischemic brains, and improve the repair of neurological functions in post-ischemic stroke rats [2]. |
| molecular weight | 947.122 |
| Molecular formula | C47H78O19 |
| CAS | 84687-45-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lee SY, et al. Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo. Phytomedicine. 2018 Jan 1;38:183-191. 2. Chen X, et al. Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injury via Activating EGFR/MAPK Signaling Cascades. Mol Neurobiol. 2018 Aug 7. |