| Description | Aristeromycin (U 99468) is a broad-spectrum antiviral antibiotic that targets RNA viruses and is an inhibitor of S-adenosylhomocysteine hydrolase (AHCY). |
| In vitro | DZNeP 和 Aristeromycin 对 AHCY 具有较高的抑制活性。用 DZNeP 处理前列腺癌细胞导致 SAH 的积累，并降低同型半胱氨酸和组蛋白 H3K27 甲基化水平。通过 siRNA 介导的 AHCY 敲低实现了 SAH 的积累和生长抑制的确认[1]。 |
| Synonyms | U 99468 |
| molecular weight | 265.27 |
| Molecular formula | C11H15N5O3 |
| CAS | 19186-33-5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (113.09 mM), Sonication is recommended. |
| References | 1. Uchiyama N, et al. Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a. Eur J Pharmacol. 2017 Oct 5;812:138-146. 2. Ishikura T, et al. Inhibition of S-adenosylhomocysteine hydrolase by purine nucleoside analogues. Nucleic Acids Symp Ser. 1983;(12):119-22. |