| Description | Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis and autophagy by decreasing Abeta load in APP/PS1 mice, and can be used to study leukemia. |
| In vitro | Apicidin (0.1-10 μM, 24 h) 以剂量依赖性方式抑制 AT-84 细胞的活力，其中 ≥1μM 的浓度导致其活力显著降低[1]。 |
| In vivo | 在小鼠肿瘤模型中，在 14 天结束时，与对照组相比，Apicidin((5 mg/kg，腹腔注射，每日 1 次) 显着抑制了肿瘤生长高达 46%[1]。 |
| Synonyms | OSI 2040 |
| molecular weight | 623.78 |
| Molecular formula | C34H49N5O6 |
| CAS | 183506-66-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (16.03 mM), Sonication is recommended. |
| References | 1. Ahn MY, et al. HDAC inhibitor apicidin suppresses murine oral squamous cell carcinoma cell growth in vitro and in vivo via inhibiting HDAC8 expression. Oncol Lett. 2018 Nov;16(5):6552-6560. |