| Description | Antipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes that exhibits analgesic activity and inhibits X-ray-induced chromosomal aberrations in human lymphocytes. |
| In vivo | Intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, resulting in significant diminution in uterine weight and total DNA compared to untreated controls[1].Antipain dihydrochloride (100 μg/g body weight; i.p.; at 12-hour intervals from 0 to 120 h or 240 to 360 h) exhibits an inhibitory effect on urethane-induced lung neoplasia in mice[2]. |
| Synonyms | Antipain 2HCl, BDBM-32804, BDBM 32804, Antipain, BDBM32804 |
| molecular weight | 677.62 |
| Molecular formula | C27H46Cl2N10O6 |
| CAS | 37682-72-7 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626. 2. Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74(9):3754‐3757. 3. Isogai E, Ishijima S, Sonoda T, Kita K, Suzuki H, Hasegawa R, Yamamori H, Takakubo Y, Suzuki N. Protease activation following UV irradiation is linked to hypomutability in human cells selected for resistance to combination of UV and antipain. Mutat Res. 1998 Jul 17;403(1-2):215-22. PubMed PMID: 9726021. 4. Souza-Silva F, Bourguignon SC, Pereira BA, Côrtes LM, de Oliveira LF, Henriques-Pons A, Finkelstein LC, Ferreira VF, Carneiro PF, de Pinho RT, Caffarena ER, Alves CR. Epoxy-α-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite. Antimicrob Agents Chemother. 2015 Apr;59(4):1910-8. doi: 10.1128/AAC.04742-14. Epub 2015 Jan 12. PubMed PMID: 25583728; PubMed Central PMCID: PMC4356828. |