| Description | antcin A is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea with strong anti-inflammatory and anti-tumor effects. |
| In vitro | Antcin A能显著抑制焦化作用，降低炎症因子的表达，抑制NLRP3炎症体的激活与组装，并显著下调KCs中NLRP3、Caspase-1和GSDMD-NT的表达[1]。 |
| In vivo | 在NAFLD小鼠中，Antcin A能够抑制小鼠肝组织的炎症反应，减少脂质沉积，下调ALT和AST的水平，从而改善小鼠的肝功能。Antcin A还能抑制肝组织中NLRP3炎症体的激活，并降低炎症因子的水平[1]。 |
| molecular weight | 454.64 |
| Molecular formula | C29H42O4 |
| CAS | 163597-24-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (109.98 mM) |
| References | 1. Ruan S, et al. Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol. 2021 Nov;100:108126. 2. Kumar KJS, et al. Antcin-A Modulates Epithelial-to-Mesenchymal Transition and Inhibits Migratory and Invasive Potentials of Human Breast Cancer Cells via p53-Mediated miR-200c Activation. Planta Med. 2019 Jul;85(9-10):755-765. |