| Description | Anserine (L-Anserine) is a dipeptide containing β-alanine and histidine, which can be found in the skeletal muscle and brain of mammals and birds. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice. |
| In vivo | Intraperitoneal administration of specific doses of anserine to hyperglycemic rats reduced hyperglycemia and plasma glucagon concentrations, whereas thioperamide eliminated the effects of anserine. Intraduodenal injection of 0.1 mg anserine to anesthetized rats after laparotomy suppressed sympathetic nerve activity and enhanced activity of the vagal gastric efferent. In addition, oral administration of anserine reduced blood glucose levels during oral glucose tolerance testing in humans. These results suggest the possibility that anserine might be a control factor for blood glucose, and that histaminergic nerves may be involved in the hypoglycemic effects of anserine |
| Synonyms | L-鹅肌肽, L-Anserine |
| molecular weight | 240.26 |
| Molecular formula | C10H16N4O3 |
| CAS | 584-85-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Insoluble H2O: 10 mM |
| References | 1. Kubomura, Daiki, Matahira, et al. Effect of anserine ingestion on the hyperglycemia and autonomic nerves in rats and humans.[J]. Nutritional Neuroscience, 2010. |