| Description | (-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces apoptosis in human cervical cancer (HeLa) cells, induces DNA damage and inhibits the growth and migration of human lung cancer h1299 cells through Bax and caspase-dependent pathways. |
| In vitro | (-)-Anonaine (50-200 μM ; 24h ; ) exhibited significant inhibition to cell growth and migration activities on human lung cancer H1299 cells.[1] (-)-Anonaine (10-200 μM) significant nuclear damages of H1299 cells were observed treatment in a comet assay, whereas higher concentrations (6 and 30 mM) of (-)-anonaine concentrations were required to cause DNA damages in an in vitro plasmid cleavage assay.[1] |
| Target activity | HepG2 cells:38.3 ± 2.3 μg/ml(CC50), HepG2 cells:23.2 ± 2.7 μg/ml |
| Synonyms | 番荔枝碱 |
| molecular weight | 265.31 |
| Molecular formula | C17H15NO2 |
| CAS | 1862-41-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.65 mg/mL (10 mM) |
| References | 1. Chen BH,et al. (-)-Anonaine induces DNA damage and inhibits growth and migration of human lung carcinoma h1299 cells. J Agric Food Chem. 2011 ; 59(6):2284-2290. 2. Chen CY, et al. (-)-Anonaine induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells. Food Chem Toxicol. 2008 ; 46(8):2694-2702. 3. Lee JJ, et al. Effects of anonaine on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Molecules. 2008 ; 13(2):475-487. 4. Gontijo DC, et al. Antiplasmodial activity and cytotoxicity, isolation of active alkaloids, and dereplication of Xylopia sericea leaves ethanol extract by UPLC-DAD-ESI-MS/MS. J Pharm Pharmacol. 2019 ; 71(2):260-269. 5. Gontijo DC, et al. Antiplasmodial activity and cytotoxicity, isolation of active alkaloids, and dereplication of Xylopia sericea leaves ethanol extract by UPLC-DAD-ESI-MS/MS. J Pharm Pharmacol. 2019 ; 71(2):260-269. |