| Description | Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. |
| In vitro | Angoline 作为 STAT3 信号通路的一种强效且选择性的抑制剂（IC50=11.56 μM），能够抑制 STAT3 的磷酸化及其靶基因表达，从而抑制具有持续激活状态的 STAT3 的人类癌细胞生长（IC50=3.14-4.72 μM）。这项工作为针对 STAT3 信号通路的抗癌药物开发提供了新颖的先导化合物。 |
| Target activity | IL-6/STAT3 signaling pathway:11.56 μM (IC50) |
| Synonyms | 6-Methoxyldihydrochelerythrine |
| molecular weight | 379.41 |
| Molecular formula | C22H21NO5 |
| CAS | 21080-31-9 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/ml (79.07 mM) |
| References | 1. Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91. |