| Description | Anemonin is a natural product from Pulsatilla chinensis Regel. |
| In vitro | Human articular chondrocytes and cartilage explants challenged with interleukin-1β (IL-1β) were treated with Anemonin. Anemonin treatment attenuated proteoglycan loss in human cartilage explants treated with IL-1β ex vivo. Anemonin delayed articular cartilage degeneration in vitro[1]. |
| In vivo | Destabilization of the medial meniscus (DMM) was performed in 10-week-old male C57BL/6J mice. Anemonin was then intra-articularly injected into the joint capsule for 8 and 12 weeks. Anemonin delayed articular cartilage degeneration in vivo. Anemonin decre |
| molecular weight | 192.17 |
| Molecular formula | C10H8O4 |
| CAS | 90921-11-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Wang Z , Huang J , Zhou S , et al. Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway[J]. Journal of Cellular and Molecular Medicine, 2017. |