| Description | Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase |
| In vivo | Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate is now more commonly used due to a more favorable therapeutic index[1] |
| Synonyms | APGA, 氨基蝶呤, 4-Aminofolic acid |
| molecular weight | 440.41 |
| Molecular formula | C19H20N8O5 |
| CAS | 54-62-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.03 mg/mL (9.15 mM), Sonication is recommended. |
| References | 1. Cole, P. D . Phase II Trial of Oral Aminopterin for Adults and Children with Refractory Acute Leukemia[J]. Clinical Cancer Research, 2005, 11(22):8089-8096. 2. Littlefield, J. W . Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants[J]. Science, 1964, 145(3633):709-710. |