| Description | Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression. |
| Synonyms | Didemethyl-ginkgetin, 穗花杉双黄酮, Amenthoflavone, 3',8''-Biapigenin |
| molecular weight | 538.46 |
| Molecular formula | C30H18O10 |
| CAS | 1617-53-4 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 34 mg/mL（63.14 mM）, Sonication is recommended. Chloroform, Dichloromethane, Ethyl Acetate: Soluble |
| References | 1. Sakthivel KM, et al. Int Immunopharmacol. 2013 Nov;17(3):907-16. 2. Lee JS, et al. Phytother Res. 2013 May;27(5):713-20. 3. Yang Y, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(7):1035-8. 4. Zhang J, et al. Burns. 2014 Aug;40(5):922-9. 5. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin[J]. European Journal of Pharmaceutical Sciences. 2021: 105786. |