| Description | α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM. |
| In vitro | In in-vivo one-trial passive avoidance paradigm show that thujone (1.25mg/kg, i.p.) significantly impaired nicotine-induced enhancement of learning and memory in Wistar rats[1]. |
| Target activity | α7 nACh:24.7μM |
| Synonyms | Thujone, ALPHA-(-)-THUJONE, α-侧柏酮, (-)-α-侧柏酮 |
| molecular weight | 152.23 |
| Molecular formula | C10H16O |
| CAS | 546-80-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.4 mg/mL (28.9 mM) |
| References | 1. Sultan A , Yang K H S , Isaev D , et al. Thujone inhibits the function of α 7 -nicotinic acetylcholine receptors and impairs nicotine-induced memory enhancement in one-trial passive avoidance paradigm[J]. Toxicology, 2017, 384:23-32. 2. Lachenmeier D W , Emmert J , Kuballa T , et al. Thujone—Cause of absinthism?[J]. forensic science international, 2006, 158(1):1-8. |