| Description | α-Cyclodextrin (Alfadex) is a soluble fiber derived from corn and has beneficial effects on weight management in obese individuals with type 2 diabetes. |
| In vivo | Alfadex preferentially reduces blood levels of saturated and trans fats in the LDL receptor knockout mice[2]. Two independent in vivo biological test systems were used, a single cell Xenopus oocyte with expressed human aquaporin for cell hydration studies and the nematode Caenorhabditis elegans for testing life span in the treated animals. Alfadex was found to enhance water uptake through aquaporins of oocytes. Furthermore, Alfadex promoted longevity in C. elegans[3]. |
| Synonyms | Alfadex, NSC269470, α-环糊精, NSC 269470, NSC-269470 |
| molecular weight | 972.84 |
| Molecular formula | C36H60O30 |
| CAS | 10016-20-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 40 mg/mL (41.12 mM) DMSO: 100 mg/mL (102.79 mM) |
| References | 1. Uesawa M, Muroi K, Ozawa K. Plasmapheresis-refractory transplantation-associated thrombotic microangiopathy successfully treated with pravastatin and limaprost alfadex. Ther Apher Dial. 2013 Aug;17(4):462-3. 2. Comerford KB, et al. The beneficial effects of α-cyclodextrin on blood lipids and weight loss in healthy humans. Obesity (Silver Spring). 2011 Jun;19(6):1200-4. 3. Szente L, et al. Effects of alpha-cyclodextrin on water transport, cell hydration and longevity. Aging (Albany NY). 2021 Jan 19;13(2):1718-1728. 4. Inoue A, et al. Lichenoid Drug Eruption Caused by Limaprost Alfadex. Acta Derm Venereol. 2016 Nov 2;96(7):997-998. |